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Important Insomnia Facts & Resources
Lack of Sleep can be DangerousInsomnia is the single most prevalent sleep disorder with an estimated 10% of the population affected. Most people know that lack of sleep makes them punchy and lousy but they are unaware of the risks to their health. For some, insomnia or sleeplessness may be a case of a few restless nights or a lifetime of poor sleep. Ten percent of the American population having insomnia nightly. The causes of insomnia differ from person to person. Society is being victimized by not getting enough sleep. There are natural supplements that will help you fall asleep, and dramatically improve your overall sleep quality, making for many well rested and productive days ahead. New research shows that sleep may be the third essential component of a long and healthy life besides good diet and exercise. One possible solution for insomnia is melatonin. Melatonin is produced by the pineal gland. It is believed to play a role in helping with jet lag and insomnia. Insomnia has many different causes and many different ways of being expressed. Could you be suffering from insomnia, you should meditate, enquire and look into anything conceivable involving insomnia. Here's just one ebook I can suggest, it's known as Solve Your Sleep ProblemsEnd Insomnia Tonight. Check out this book on natural cures for sleep problems "...Healthy Sleep: A Guide To Natural Sleep Remedies!" Always remember : The consequences brought about by an insomnia disorder may not be as ordinary as it may seem. You'll find an article will serve you in your quest to cure your lack of sleep. Insomnia Eszopiclone for treatment of transient and chronic insomnia Synopsis Eszopiclone (Lunesta), a nonbenzodiazepine hypnotic agent, is indicated for the treatment of transient and chronic insomnia. Its mechanism of action is related to its activity at [gamma]-amino-butyric acid receptors. (1) Eszopiclone is an isomer of the hypnotic zopiclone (Imovane), which has been available in countries outside the United States for almost 20 years. (2) Safety The duration of action of eszopiclone is approximately eight hours, similar to zolpidem (Ambien) and longer than zaleplon (Sonata). The drug is metabolized in the liver by the CYP450 3A4 system, and dose adjustment is warranted in patients taking enzyme inhibitors such as ketoconazole (Nizoral). Eszopiclone is a Schedule IV con-trolled substance. No evidence of tolerance or dependence has been reported. (3,4) One case of nonfatal overdose with 36 mg of eszopiclone was reported in clinical trials. Rare cases of fatal overdose with zopiclone and concomitant central nervous system (CNS) depressants have been reported in European post-marketing studies. (1) Eszopiclone is pregnancy category C (animal studies only) and it is not approved for use in children. Tolerability Unpleasant taste (34 versus 3 percent), headache (17 versus 13 percent), and dizziness (7 versus 4 percent) were reported more commonly in patients taking eszopiclone than those taking placebo, respectively, in clinical trials. (1) Additive side effects are expected with concomitant use of substances with CNS-depressant activity, including alcohol. (1) 
CHANGE THIS TO ADD A NEW PARAGRAPH, COUPLE OF SENTENCES. YOU COULD EVEN ADD AND IMAGE OR AFFILIATET LINK. DO SOME REASEARCH ADD UNIQUE CONTENT AND WHATEVER YOU PLACE HERE WILL SHOW UP ON ALL YOUR ARTICLE PAGES IN THE TOP SECTION OF THE PLR ARTICLE Effectiveness There has been little published research on the effectiveness of eszopiclone in patients who have difficulty sleeping. One study (3) analyzed the use of eszopiclone for six months in 791 adult patients with chronic insomnia (age = 21 to 69 years; 63 per-cent were women). Patients reported results once weekly through an interactive voice response system and completed monthly study visits for safety and compliance assessments. After one week of therapy, eszopiclone-treated patients fell asleep a mean of 37 minutes faster, had 0.6 fewer nighttime awakenings, and slept 50 minutes longer than placebo-treated patients. Sleep quality, next-day daytime ability to function, daytime alertness, and sense of physical well-being also were improved. The effect on sleep was maintained but attenuated; at six months, eszopiclone-treated patients fell asleep approximately 16 minutes faster, had 0.7 fewer nighttime awakenings, and slept 39 minutes longer than placebo-treated patients. No studies have compared eszopiclone with non-drug insomnia therapy, zolpidem, zaleplon, or other sedative hypnotic agents. Price A one-month supply of eszopiclone (1-, 2-, or 3-mg tablets) will cost patients approximately $111. This price is slightly higher than the cost of comparable agents, such as zolpidem (5 mg, $81-9) or zaleplon (5 mg, $71), and is much more expensive than older benzodiazepine hypnotics. Simplicity The recommended starting dose of eszopiclone is 2 mg at bedtime for patients who can remain in bed for at least eight hours. (2) The dose may be increased to 3 mg at bedtime based on patient response. (1) The starting dose should be reduced to 1 mg for patients with severe liver disease, those taking potent CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin [Biaxin], nelfinavir [Viracept]), and patients older than 65 years. The onset of action of eszopiclone may be delayed if taken with or immediately after a high-fat meal. (1) Bottom Line Similar to other hypnotic drugs, eszopiclone treats the symptom of insomnia and not the underlying cause. It offers no advantage over other nonbenzodiazepine hypnotic agents for transient insomnia and it therefore should be considered a second-line agent. As with other drugs in this class, it should not be used routinely. Although labeled for this use, long-term, continuous use of eszopiclone should be reserved for those few patients who require nightly therapy and who are able to afford the drug and tolerate the side effects. Starting ApproximateName dosage Dose form monthly cost *Eszopiclone (Lunesta) 1 to 2 mg 1-, 2-, and $111 for 30 at bedtime 3-mg tablets tablets*--Average wholesale cost, based on Red Book. MontvBook.REFERENCES (1.) Lunesta (package insert). Marlborough, Mass.: Sepracor, Inc., 2004. Accessed online May 2, 2005, at: http://www.lunesta.com/PostedApprovedLabelingText.pdf. (2.) Eszopiclone (Lunesta), a new hypnotic. Med Lett Drugs Ther 2005;47:17-9. (3.) Krystal AD, Walsh JK, Laska E, Caron J, Amato DA, Wessel TC, et al. Sustained efficacy of eszopiclone over 6 months of nightly treatment: results of a randomized, double-blind, placebo-controlled study in adults with chronic insomnia. Sleep 2003;26:793-9. (4.) Zammit GK, McNabb LJ, Caron J, Amato DA, Roth T. Efficacy and safety of eszopiclone across 6-weeks of treatment for primary insomnia. Curr Med Res Opin 2004;20:1979-91. The Authors ANDREA M. WESSELL, PHARM.D., B.C.P.S., C.D.E., is assistant professor, and C. WAYNE WEART, PHARM.D., B.C.P.S., is a professor in the Department of Pharmacy and Clinical Sciences, and Department of Family Medicine, Medical University of South Carolina Colleges of Pharmacy and Medicine, Charleston, South Carolina COPYRIGHT 2005 American Academy of Family Physicians Insomnia and Sleep InformationScott Parat has compiled and placed these pages on the web for the benefit of anyone suffering from insomnia. Scott has been involved in the health field for the last 20 years and focuses much of his attention toward natural solutions to health problems. Insomnia SymtomsYou don't have to suffer with your sleep problems, try these natural cures and consult your doctor. Discover how to Cure Your Insomnia without Drugs If you are experiencing a variety of medical conditions, insomnia often times creeps in. I experienced this myself. In fact almost a 2 years went by before I realized I wasn't sleeping at night. I could only tell how bad it was, because after my doctor visit I was given a prescription sleep aid. I didn't want to take it. The first night I took it I sleep through the night for the first time in years.....I never knew what I was missing! Is Procrastination Keeping You Awake?Going to bed while you have
countless things pulling at the corners of your mind can only mean one thing -
insomnia. In order to sleep our minds have to relax to a point where our body
naturally falls asleep. If you're busy thinking about all of the things that you
didn't accomplish the day before, you won't be able to fall asleep. Worry is a
powerful e ... Trying to fall asleep when
the tap is dripping or the wind is whipping outside can be an effort in
futility. Regardless of how hard you try, you just cannot get past the noise and
fall asleep. A few minutes turns into an hour and it's not just insomnia
bothering you but you're becoming angry realizing that the loss of sleep you are
feeling tonight will have an im ... |
